QixiaXidouya mining area is an important gold mining area within Qixia gold metallogenic belt in eastern Shandong province. Based on geological investigations, samples of intermediateacidic to acidic intrusive rocks that are spatially closely related to gold mineralization within the mining area have been collected systematically, and zircon UPb dating and SHRIMP oxygen isotope analysis have been conducted. It is indicated that quartz diorite porphyry has a diagenetic age ranging from 155.2Ma to 153.9Ma, while the biotite monzogranite has a diagenetic age ranging from 159.7Ma to 155.7Ma. They both belong to Linglong granite sequence. The zircon δ18O values in the two types of intrusive rocks show a relatively small range, varying between 3.72‰ and 9.85‰ (with an overall average of 7.11‰), and exhibiting the characteristics of high δ18O. The quartz diorite porphyry and biotite monzogranite have similar diagenetic ages and zircon oxygen isotope compositions. It is indicated that they represent a homologous magmatic evolution relationship. The oxygen isotopes of zircons from neutral acidic intrusive rocks in Xidouya mining area of Qixia city show obvious crustal characteristics. it reflects the superposition of multiple geological processes, including crustal contamination, subduction zone fluid interaction, sediment recycling, cratonic mantle enrichment and regional metamorphism.