During the formation process of groundwater in Lubei area in Shandong province, due to the influence of ancient geography and climate, vertical zoning of groundwater quality has been formed. In recent years, the development and utilization of geothermal water in this area have been distributed extensively. Studying hydraulic connection between geothermal water and the overlying deep groundwater aquifer is of great significance for promoting geothermal water extraction and analyzing the impact of geological environmental effects. In this paper, the exploitation characteristics, groundwater flow field characteristics, water level change characteristics and hydrochemical characteristics of thermal reservoirs and overlying deep groundwater aquifers have been compared and analyzed. It is regarded that hydraulic connection between the two aquifers is extremely weak and constitutes two independent groundwater aquifer systems.