In coal mining, gas disasters are a critical issue restricting the safe operation of mines. As the primary pathway for gas migration and accumulation, the fractured zone in the roof strata plays a key role, so its control technologies are very essential. Taking the 11203 working face of Changxing coal mine as an example, an advanced negativepressure gas drainage technique has been put forward based on highlevel boreholes. By precisely laying the boreholes in fracture developed zones, drainage of original gas has been realized. As showed by field tests, under a negative pressure of 60 kPa, gas concentration of 1# borehole can reach 59.05%. When the pressure dropped to 31 kPa, and 1# borehole and 2# borehole operate at the same time, the instantaneous pure gas flow can increase to 28.23 m3/min, and the cumulative volume of mixed gas extraction can reach 3,140,156.83 m3. it has increased nearly 10 times and 22 times respectively comparing to operation under 60 kPa. Furthermore, the absolute gas emission from the working face has decreased from 13.80 m3/min to 8.52 m3/min, and the reduction rate is 38.3%. It is indicated that this technique has significantly enhanced gas drainage efficiency and proactive control capabilities. It is especially suitable for deep, highgas and fracture developed coal strata. It will provide a new approach for proactive gas disaster prevention and control in karst regions in southwest China.